The Alli program starts with your commitment to adopting healthy eating habits. It combines the only over-the-counter, FDA-approved weight loss aid with an individually tailored support plan, to help achieve gradual and healthy weight loss. When you take Alli along with a reduced-calorie, low-fat diet, you can lose about 50% more weight than dieting alone. For example, instead of losing 10 pounds with diet alone, you can lose 15 pounds with the Alli program.